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2015年ASCO GI研讨会将于1月15日～17日在美国旧金山举行。幽门螺杆菌感染是否会影响胃癌的临床特征？在1月15日食管癌和胃癌壁报区展出了一项关于这一问题的研究，医脉通将该项研究摘要整理编译，供大家参考：

研究背景

根据胃癌患者是否感染幽门螺杆菌（Hp），会使胃癌的呈现不同特征的观点目前仍存在争论。本项研究的目的是在Hp-阳性（HpP）和Hp-阴性（HpN）胃癌患者之间，比较胃癌的临床特征，病理学特征和预后。

研究方法

研究人员对2003年6月到2010年12月之间在首尔国立大学Bundang医院诊断为胃癌的患者进行了回顾。他们利用组织学检查和快速尿素酶试验（RUT）对Hp状态进行评估。病理阳性的和/或RUT阳性的患者被归类为HpP。萎缩性胃炎和/或组织学上肠化生患者也被列为HpP。组织学和RUT阴性患者定义为HpN。

研究结果

HpP和HpN患者的数量分别为852（62.6%）和509（37.4%）。HpP胃癌患者相比于比HpN患者窦状位置更为常见（51.8% vs 44.9%，P=0.003）。而且，与HpP患者相比较，HpN患者的胃癌分期较高（IV期 17.9% vs 9.6%，P＜0.001）。根据Hp感染情况，年龄，患者性别，和胃癌Lauren分类没有差异。HpN胃癌患者的复发率和死亡率显著高于HpP胃癌患者（P=0.002和P=0.001）。

研究结论

根据幽门螺杆菌状态不同，胃癌患者有不同的临床和病理特征。HpN胃癌患者相比于HpC或者HpP胃癌患者会表现较差的预后。

英文摘要：

‍‍Characteristics and prognosis of gastric cancer according to Helicobacter pylori.（Abstract 14）

Background：Different features of gastric cancer according to Helicobacter pylori(Hp) infection is still under debate. The aim of this study was to compare clinical, pathologic characteristics and prognosis of gastric cancer between Hp-positive (HpP) and Hp-negative (HpN) gastric cancer. 

Methods：Patients diagnosed as gastric cancer in Seoul National University Bundang hospital from June 2003 to December 2010 were reviewed. Status of Hp was evaluated by histology and rapid urease test (RUT). Patients who had positive histology and/or positive RUT were classified as HpP. Patients who had atrophic gastritis and/or intestinal metaplasia from histology were also classified as HpP. Patients who had both negative histology and RUT were defined as HpN. 

Results：The number of patients with HpP and HpN were 852 (62.6%) and 509 (37.4%), respectively. Antral location was more common in gastric cancer with HpP than in those with HpN (51.8% vs 44.9%, P = 0.003). Stage of gastric cancer was higher in patients with HpN than in patients with HpP (stage IV 17.9% vs 9.6%, P < 0.001). Age, sex of patients and Lauren classification of gastric cancer was not different according to Hp status. Recurrence and mortality was significantly higher in patients with HpN gastric cancer than those in HpP gastric cancer (P = 0.002 and P= 0.001). 

Conclusions：Gastric cancers have different clinical and pathologic features according to the Hp status. Patients with HpN gastric cancers have poorer prognosis than those with HpC or HpP gastric cancers.

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